解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS:Samples were collected on filter paper f...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-372
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:Public health pesticides has been the mainstay control of vectors of malaria and other diseases, and public health pests, but there is increasing concern over how these pesticides are being managed. Poor pesticide management could lead to risks to human health and the environment, or diminish the effectivene...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-368
更新日期:2014-09-18 00:00:00
abstract:BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-356
更新日期:2014-09-10 00:00:00
abstract:BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-331
更新日期:2014-08-24 00:00:00
abstract:BACKGROUND:The Plasmodium falciparum protein RH5 is an adhesin molecule essential for parasite invasion of erythrocytes. Recent studies show that anti-PfRH5 sera have potent invasion-inhibiting activities, supporting the idea that the PfRH5 antigen could form the basis of a vaccine. Therefore, epitopes recognized by ne...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-326
更新日期:2014-08-18 00:00:00
abstract:BACKGROUND:Tumour necrosis factor (TNF) and interferon gamma (IFN-γ), encoded by TNF-836 C/A (rs 1800630) and IFN-γ -1616 C/T (rs2069705) genes, are key immunological mediators that are believed to both play protective and pathological roles in malaria. The aim of this study was to investigate the relationship between ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-314
更新日期:2014-08-13 00:00:00
abstract:BACKGROUND:The massive deployment of life saving malaria interventions has not only resulted in a decline in disease burden but a change in the risk of infection and disease. The study reassesses the importance of known risk factors and reviews demographic and socio-economic determinants of malaria risk in the populati...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-306
更新日期:2014-08-08 00:00:00
abstract:BACKGROUND:Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-300
更新日期:2014-08-06 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current study was to assess access to Kenya's policy recommended anti-malarials, ACT and quinine i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-290
更新日期:2014-07-28 00:00:00
abstract::While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to be effective, limited disease transmission, achieved through rapid...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-13-291
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:Early and accurate diagnosis of Plasmodium falciparum infection is important for providing appropriate treatment to patients with malaria. However, technical limitations of currently available diagnostic tests limit their use in control programs. One possible explanation for the vulnerability of current anti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-277
更新日期:2014-07-18 00:00:00
abstract:BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-13-263
更新日期:2014-07-09 00:00:00
abstract:BACKGROUND:The effects that artemether-lumefantrine (AL) has on gametocyte dynamics in the short-term have recently been described. However there is limited long-term longitudinal data on the effect of AL on gametocyte dynamics in asymptomatic children. METHODS:An epidemiological study was conducted in Kombewa, Wester...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-13-265
更新日期:2014-07-09 00:00:00
abstract:BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-248
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of T76 mutation in the pfcrt gene. This situation has several health implications, one being that mutations that confer resistance ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-246
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-244
更新日期:2014-06-25 00:00:00
abstract:BACKGROUND:Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) programmes in particular. CASE DESCRIPTION:The institutional evolution of a city-level, community-based LSM programme over 14 y...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-245
更新日期:2014-06-25 00:00:00
abstract:BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-243
更新日期:2014-06-24 00:00:00
abstract:BACKGROUND:The counterfeiting of anti-malarials represents a form of attack on global public health in which fake and substandard anti-malarials serve as de facto weapons of mass destruction, particularly in resource-constrained endemic settings, where malaria causes nearly 660,000 preventable deaths and threatens mill...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-13-209
更新日期:2014-06-02 00:00:00
abstract:BACKGROUND:The recent reports on the decreasing susceptibility of Plasmodium falciparum to artemisinin derivatives along the Thailand and Myanmar border are worrying. Indeed it may spread to India and then Africa, repeating the same pattern observed for chloroquine resistance. Therefore, it is essential to start monito...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-207
更新日期:2014-05-31 00:00:00
abstract:BACKGROUND:Traditional medicine is readily available in Tanzania, and local terms like degedege is widely used for malaria-like illnesses, often associated with supernatural forces. Malaria prevention and intervention efforts can benefit from policy-makers' awareness of local perceptions and beliefs in the rural areas ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-200
更新日期:2014-05-28 00:00:00
abstract:BACKGROUND:There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-197
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-190
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-192
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-181
更新日期:2014-05-11 00:00:00
abstract:BACKGROUND:Due to the development of resistance to synthetic insecticides, adverse effects to human health, non-target organisms and the environment, there is an urgent need to develop new insecticides, which are effective, safe, biodegrable and target-specific. This study was undertaken to evaluate the adulticidal act...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-173
更新日期:2014-05-06 00:00:00
abstract:BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-172
更新日期:2014-05-05 00:00:00
abstract:BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-163
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-157
更新日期:2014-04-23 00:00:00
abstract:BACKGROUND:The accuracy of the World Health Organization method of estimating malaria parasite density from thick blood smears by assuming a white blood cell (WBC) count of 8,000/μL has been questioned in several studies. Since epidemiological investigations, anti-malarial efficacy trials and routine laboratory reporti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-145
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:Malaria and schistosomiasis are endemic and co-exist in the same geographic areas, even co-infecting the same host. Previous studies have reported that concomitant infection with Schistosoma japonicum could offer protection against experimental cerebral malaria (ECM) in mice. This study was performed to eval...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-116
更新日期:2014-03-26 00:00:00
abstract:BACKGROUND:Effective surveillance systems are required to track malaria testing and treatment practices. A 26-week study "SMS for Life" was piloted in five rural districts of Kenya to examine whether SMS reported surveillance data could ensure real-time visibility of accurate data and their use by district managers to ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-107
更新日期:2014-03-19 00:00:00
abstract:BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-103
更新日期:2014-03-17 00:00:00
abstract:BACKGROUND:Malaria remains a major public health problem, and its control has been hampered by drug resistance. For a number of drugs, Plasmodium falciparum single nucleotide polymorphisms (SNPs) are associated with altered drug sensitivity and can be used as markers of drug resistance. Several techniques have been stu...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-95
更新日期:2014-03-14 00:00:00
abstract:BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-86
更新日期:2014-03-10 00:00:00
abstract:BACKGROUND:Information is needed on the expected durability of insecticidal nets under operational conditions. The persistence of insecticidal efficacy is important to estimate the median serviceable life of nets under field conditions and to plan for net replacement. METHODS:Deltamethrin residue levels were evaluated...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-80
更新日期:2014-03-06 00:00:00
abstract:BACKGROUND:Programmes of pre-elimination of malaria have been implemented in Senegal since 2010, and the burden of malaria has decreased substantially. These changes in the epidemiology should be monitored with effective tools that allow changes in patterns of transmission to be estimated. In Dielmo and Ndiop, two vill...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-83
更新日期:2014-03-06 00:00:00
abstract::Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather th...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-13-62
更新日期:2014-02-20 00:00:00
abstract:BACKGROUND:The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands. And, there is a push for intensified vector control in Guadalcanal, to improve the livelihood of residents and to minimize the number of cases, which are regularly exported to the rest of the country. The...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-56
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection and quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-bas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-55
更新日期:2014-02-14 00:00:00